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Istradefylline 40 mg/day increased peak amounts and AUC of CYP3A4 substrates in medical trials. This outcome was not observed with istradefylline 20 mg/working day. Think about dose reduction of sensitive CYP3A4 substrates.crizotinib increases levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Dose redu